Application Of Transgenic Animals Wikipedia
Transgenic applications used in animals to enhance disease resistance include the transfer of major histocompatibility complex genes T-cell receptor genes and immunoglobulin genes.
Application of transgenic animals wikipedia. Transgenic animals are a source of several recombinant proteins like enzymes blood. However the realization of genetically engineered livestock has been much slower. These animals can be helpful in producing organs growth hormones and useful proteins for the humans.
Transgenic animals ie engineered to carry genes from other species have the potential to improve human welfareAlthough there are many ethical issues surrounding transgenesis this presentation focuses on its applications in agriculture medicine and industry. The six applications are. This results in a proportion of animals carrying the transgene in the germ line which may be high in some species eg.
A number of methods are currently in use for the creation of transgenic animals. The application of transgenic animals showed that within the next five to eight years genetically modified animals will play a significant and important role in the biomedical field in particular via the production of valuable pharmaceutical proteins and the supply of xenografts. Applications Transgenic models for Alzheimer disease amyotrophic lateral sclerosis Huntington disease arthritis muscular dystrophy tumorigenesis hypertension neurodegenerative disorders endocrinological dysfunction coronary disease etc.
One favoured method involves the inoculation of the DNA into the pronucleus of a fertilised ovum followed by implantation into pseudo pregnant females. These transgenic models are used in research for the development of medicines. Transgenic constructs bearing the immunoglobulin A LA gene have successfully introduced into pigs sheep and mice in an attempt to increase resistance against infections.
The production of transgenic animals has focused mainly on producing models eg the mouse for basic and medical research. For example we have transgenic models for diseases such. This article throws light upon the six applications of transgenic plants.
Transgenic mice are used for testing the safety of vaccines. Moreover in order to devise a cure for these diseases the transgenic animals are used as model organisms. Transgenic animals are used to produce proteins which are important for medical and pharmaceutical applications.
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